Background :
@ES The immunologic mechanism of alopecia areata is not definitely confirmed although alopecia areata is regarded as a disease occuring from certain immunologic process.
T lymphocyte infiltration in and around hair follicle demonstrated by many investigators and frequent detection of patients with alopecia areata suggest that certain systemic factors are related to the development of alopecia areata. But, the
changes of
T lymphocyte of the peripheral blood in patients with alopecia areata is not confirmed despite of many investigations.
@ES Object :
@EN The purposes of of this study were to determine the changes of T lyphocyte of the peripheral blood in the patients with alopecia areata compared with normal control subjects and to compare T lymphocyte subsets(CD3, CD4, CD8, CD4/CD8 ration
and
CD1)
based on activity, extent and duration of disease within patients with alopecia areata.
@ES Methods :
@EN We performed analysis of T lymphocyte subsets of the peripheral blood in 38 patients with alopecia areata and 307 normal control subjects using flow cytometry. The patients with alpecia areata were subdivided into active and stable based on
activity, on activity, into patchy, diffuse and alopecia totalis and alopecia universalis based on severity and into less than one year and more than one year based on duration and T lymphocyte subsets were compared according to subdivision.
@ES Result :
@EN In the patients with alopecia areata. Total T lymphocyte, helper/inducer T lymphocyte and suppressor/cytotoxic T lymphocyte were decreased and helper/suppressor ratio and CD1 were increased compared with normal control subjects(p<0.001). CD1
was
inereased in active alopecia areatacompared with stable alopecia areata(p<0.05). But, there were no significant differences in total T lymphocyte, helper/inducer T lymphocyte. Suppressor/cytotoxic T lymphocyte and helper/suppressor ratio betwween
active
and stable alopecia areata(p>0.05). Also, there were no signifi cant differences in total T lymphocyte, helper inducer T lymphocyte, suppressor / cytotoxic T lymphocyte, helper/suppressor ratio and CD1 compared based on extent and duration of
disease(p>-0.05).
@ES Conclusion :
@EN From the above result it is suggested that the decrease of suppressor T lymphocyte is related to development of alopecia areata and CD1 is related to activity of disease.
(Kor J Dermatol 1996;34(4) : 600~607)
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